Myosin Transition State Complex - Pre Power Stroke
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We show the structures of the motor domains and essential light chain domain construct , crystallized in the presence of the transition state analogue ADP.ALF4-and solved by Dominguez et al.Cell 94,559-572 (1998). This shows a substantial change in the 'converter region' and in the lever. A hypothesis is proposed about how this change is communicated through the actin binding site to the nucleotide binding site and then through to the lever arm.